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Comedy veteran Jerry Stiller, who launched his career opposite wife Anne Meara in the 1950s and reemerged four decades later as the hysterically high-strung Frank Costanza on the smash television show Seinfeld, died at 92, his son Ben Stiller announced Monday.

He died of natural causes, his son — a comedy star himself — said in a tweet.

Jerry Stiller was a multi-talented performer who appeared in an assortment of movies, playing Walter Matthau’s police sidekick in the thriller The Taking of Pelham One Two Three and Divine’s husband Wilbur Turnblad in John Waters’ twisted comedy Hairspray.

He also wrote an autobiography, “Married to Laughter,” about his 50-plus year marriage to soul mate and comedic cohort Meara, who died in 2015. And his myriad television spots included everything from Murder She Wrote” to Law and Order — along with 36 appearances alongside Meara on “The Ed Sullivan Show.”

Stiller, although a supporting player on Seinfeld, created some of the Emmy-winning show’s most enduring moments: co-creator and model for the “bro,” a brassiere for men; a Korean War cook who inflicted food poisoning on his entire unit; an ever-simmering salesman controlling his explosive temper with the shouted mantra, “Serenity now!”

While he was known as a nut-job father on the small screen, Stiller and wife Meara raised two children in their longtime home on Manhattan’s Upper West Side: daughter Amy, who became an actress, and son Ben, who became a writer, director and actor in such films as Dodgeball, There’s Something About Mary and Meet the Parents.