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Scarlett Johansson’s plans to portray a transgender man have sparked a backlash from many who object to cisgender actors playing trans roles.

Earlier this week, Johansson was announced to star in Rub & Tug, a film about prostitution ring leader Dante “Tex” Gill, who was born Lois Jean Gill but identified as a man. Since the announcement, transgender actors and advocates have criticized the production for not casting a trans actor in the role.

Johansson, who’s also producing the film, further inflamed critics with a statement to the website Bustle, via her representative, that said criticism “can be directed to Jeffrey Tambor, Jared Leto, and Felicity Huffman’s reps for comment.”

Tambor, Leto and Huffman are all cisgender actors who received acclaim for playing trans characters. Tambor won two Emmys for his performance on “Transparent,” though he departed the show last year after he was accused of sexual misconduct by two transgender women: actress Trace Lysette and his former personal assistant, Van Barnes. Leto won an Oscar for his performance in 2013′s “Dallas Buyers Club.” Huffman was nominated for an Oscar for the 2005 film “Transamerica.”

Lysette was among those who disapproved of Johansson’s intentions. On Twitter, she wrote:

Other Twitter users have also called out the actress for 'blindly' accepting any role.

Jamie Clayton, a transgender actress who stars in Netflix’s “Sense8,” dared Johansson and the filmmakers to cast trans actors in non-trans parts.

“Actors who are trans never even get to audition for anything other than roles of trans characters,” Clayton said in an all-caps tweet. “That’s the real issue. We can’t even get in the room.”

Representatives for Johansson didn’t respond to messages for comment.

Johansson has come under fire before for playing a role that prompted some outrage. In last year’s “Ghost in the Shell,” she played the robot character known in Masamune Shirow’s original manga series as Motoko Kusanagi.

Critics called it another example of Hollywood’s long history of whitewashing Asian characters with Caucasian actors. Mamoru Oshii, director of the original anime adaptation of “Ghost in the Shell,” defended the casting because Johansson’s role was a cyborg with no fixed race.

Rupert Sanders, who directed “Ghost in the Shell,” is set to helm “Rub & Tug.”